Knowing, being, and doing: Aboriginal and non-aboriginal collaboration in cancer services

This qualitative inquiry explored the processes and practices of collaboration as experienced by a group of Australian multidisciplinary Aboriginal and non-Aboriginal health workers. Each worker had participated, for a period of 2 to 5 years, in an Australian Government–funded project in which a range of health initiatives led to improved access to cancer services by Aboriginal communities in a rural region of South Eastern Australia. Initiatives which addressed high rates of mortality from cancer, poor access to cancer screening, and engagement with cancer treatment were developed through the formation of close working relationships between Aboriginal and non-Aboriginal health workers. These relationships were regarded as personally and professionally transformative. Through the sharing of knowledge, skills, and experiences, new ways of knowing, being, and doing emerged. Developing a deeper understanding of cross-cultural collaboration is one way of addressing complex health problems and building the capacity of the health workforce

Understanding food consumption lifecycles using wearable cameras

Application of design in HCI is a common approach to engendering behavioural change to address important challenges such as sustainability. Encouraging such change requires an understanding of current motivations and behaviours in the domain in question. In this paper, we describe use of wearable cameras to study motivations and behaviours around food consumption by focusing on two contrasting cultures, Malaysia and the UK. Our findings highlight the potential of wearable cameras to enhance knowledge of food consumption practices and identify where and how some digital interventions might be appropriate to change food behaviour. This includes appealing to people’s motivations behind food consumption and capitalising on existing practices such as gifting of food and social meals. We propose a food consumption lifecycle as a framework to understand and design human–food interaction. The use of wearable cameras enabled us to capture a high-level overview of spatially distributed food-related practices and understand food behaviours in greater depth.This work was co-funded by Horizon Digital Economy Research Institute, UK, and Crops for the Future, Malaysia.This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s00779-015-0871-

Wearables or infrastructure: contrasting approaches to collecting behavioural data in the home

This paper examines and contrasts two approaches to collecting behavioural data within the home. The first of these involves filming from static video cameras combined with network logging to capture media consumption activities across multiple screens. The second utilises wearable cameras that passively collect still images to provide insights into food related behaviours. The paper compares the approaches from the perspective of the researchers and participants, and outlines the key benefits and challenges of each, with the aim of further mapping the space of possibilities now available when studying behaviour in the home

Wearables or infrastructure: contrasting approaches to collecting behavioural data in the home

This paper examines and contrasts two approaches to collecting behavioural data within the home. The first of these involves filming from static video cameras combined with network logging to capture media consumption activities across multiple screens. The second utilises wearable cameras that passively collect still images to provide insights into food related behaviours. The paper compares the approaches from the perspective of the researchers and participants,and outlines the key benefits and challenges of each, with the aim of further mapping the space of possibilities now available when studying behaviour in the home

A glycosylation-dependent pathway of non-canonical VEGFR2 activation links tumor hypoxia to vascular remodeling and immunity.

The mechanisms linking tumor hypoxia, neovascularization and immunity are poorlyunderstood. Resistance to VEGF-targeted antiangiogenic therapies suggests thecontribution of non-canonical pathways to hypoxia-driven neovascularization. Wepreviously demonstrated an essential role of galectin-1 (Gal-1) in the control of tumorgrowth by favoring tumor-immune escape. The present study was conducted to elucidatewhether Gal1-glycan lattices link tumor hypoxia to neovascularization and to investigatewhether disruption of these lattices using an anti Gal1 mAb, may contribute to remodelingtumor vascular networks and stimulation of anti-tumor immune responses. For thispurpose, we first examined the ?glycosylation signature? of endothelilal cells (ECs) in restingconditions or exposed to proliferative, tolerogenic, inflammatory or hypoxic stimuli. Incontrast to ECs stimulated with pro-inflammatory stimuli, ECs exposed to tolerogenic,proliferative or hypoxic microenvironment exhibited a substantial up-regulation of therepertoire of cell surface glycans that are critical for Gal-1 binding and angiogenesis(p<0.01). Screening of the phosphorylation status of a spectrum of growth factor receptorsrevealed a 2-fold increase in phosphorylation of VEGFR2, Akt and Erk1/2 upon exposureto Gal1, a pattern comparable to that induced by VEGF. In this regard, pharmacologicalinhibition of Akt or Erk1/2 or interruption of GnTV-mediated N-glycan branching (but notGCNT1-mediated core 2-O-glycan elongation) prevented Gal1 signaling and abrogatedECs proliferation (p<0.01), migration (p<0.01) and angiogenesis (p<0.05). Co-Ipexperiments revealed specific association of Gal1 with VEGFR2 through N-glycandependentinteractions. Consistently, VEGFR2 blockade prevented Gal1-induced ECsmigration (p<0.01) and morphogenesis (p<0.05), whereas blockade of VEGFR1, VEGFR3,or VEGF had no effect, suggesting that signaling established between lectins and glycansmight serve as alternative pathways by mimicking ?cognate ligands?, thus preserving criticalprocesses such as angiogenesis. Furthermore, hypoxia promoted ROS/NF-B-dependentHIF-1-independent up-regulation of tumor Gal1 (p<0.01). mAb- or shRNA-mediateddisruption of Gal1-glycan lattices attenuated hypoxia-driven angiogenesis, while promotingpericyte maturation and vascular remodeling as shown by increased association of ECswith mature pericytes (SMA+, desmin+ and RGS5-) (2-fold; p<0.01), decreased vesseldiameter (2.7 fold; p<0.01) and alleviation of hypoxia in tumors treated with anti-Gal1 mAb.Moreover, anti-Gal-1 mAb-treated tumors showed a significant reduction in tumor growth(p<0.01) and evoked a T-cell specific immune response, as shown by increased T-cellproliferation (p<0.01) and augmented IFN- (p<0.05) and IL-17 (p<0.05) productioncompared to mice receiving control isotype. Moreover, tumor draining LN of mAb-treatedmice had lower frequency of regulatory T cells (p<0.05) and lower IL-10 secretion (p<0.05)compared to mice receiving isotype control. Hence, disruption of lectin-glycan lattices, notonly evokes an unleashed anti tumor immune response, but also reduces angiogenesisand favors remodeling of tumor vascular networks, highlighting the versatility ofendogenous lectins and the dynamics of the ?glycome? during cancer progression.Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Salatino, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ouyang, J.. Dana Farber Cancer Institute;Fil: Rubinstein, N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mascanfroni, Ivan Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Cerliani, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ilarregui, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sundblad, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Domaica, Carolina Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Dergan Dylon, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Croci, M. C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Albini, A.. Istituto Nazionale di Ricovero e Cura a Carattere Scientifico "Saverio de Bellis"; ItaliaFil: Shipp, M. A.. Dana Farber Cancer Institute;Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaKeystone simposia on molecular and celullar biology: new frontiers at the interface of immunity and glycobiologyLake LouisCanadákeystonesymposi

The Timestreams platform: artist mediated participatory sensing for environmental discourse

Ubiquitous and pervasive computing techniques have been used to inform discourses around climate change and energy insecurity, traditionally through data capture and representation for scientists, policy makers and the public. Research into re-engaging the public with sustainability and climate change issues reveals the significance of emotional and personal engagement alongside locally meaningful, globally-relevant and data-informed climate messaging for the public. New ubiquitous and pervasive computing techniques are emerging to support the next generation of climate change stakeholders, including artists, community practitioners, educators and data hackers, to create scientific data responsive artworks and performances. Grounded in our experiences of community based artistic interventions, we explore the design and deployments of the Timestreams platform, demonstrating usages of ubiquitous and pervasive computing within these new forms of discourse around climate change and energy insecurity